Glycine receptor antibodies in PERM: a new channelopathy.
نویسندگان
چکیده
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منابع مشابه
Anti-Glycine Receptor Antibody Mediated Progressive Encephalomyelitis with Rigidity and Myoclonus Associated with Breast Cancer
We describe a 66-year-old woman who presented with a dramatic course of PERM. Anti-glycine receptor antibodies were found. She stabilized after plasma-exchange and partly recovered. Eighteen months later, a diagnosis of smouldering breast cancer with bone marrow metastasis was made. There are indications that this tumor was already present at first presentation. An overview of PERM and anti-gly...
متن کاملThymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis
We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated progre...
متن کاملProgressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.
BACKGROUND The syndrome of progressive encephalopathy with limb rigidity has been historically termed progressive encephalomyelitis with rigidity and myoclonus (PERM) or stiff-person syndrome plus. METHODS The case is presented of a previously healthy 28-year-old man with a rapidly fatal form of PERM developing over 2 months. RESULTS Serum antibodies to both NMDA receptors (NMDAR) and glyci...
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A 62-year-old woman with one-year history of type 1 diabetes mellitus was admitted to our hospital with progressive weakness in the lower extremities and urinary dysfunction following high fever. On admission, she had rigidity and myoclonus in the upper extremities with sensory ataxia. Cerebrospinal fluid examination revealed mild pleocytosis and oligoclonal band. Glutamic acid decarboxylase (G...
متن کاملSynaptic AMPA Receptor Insertion during LTP 249 Figure 6. Glycine Treatment Enhances NMDA Receptor–Dependent Cell Surface Expression of AMPA Receptors in Cultured Hippocampal Neurons
Figure 6. Glycine Treatment Enhances NMDA Receptor–Dependent Cell Surface Expression of AMPA Receptors in Cultured Hippocampal Neurons Examples of fluorescent images obtained with a CCD camera (A) illustrate the specific labeling of AMPA receptors expressed on the plasma membrane surface or in the entire cell. Receptors expressed on the cell surface (red) or in the entire cell (green) were sequ...
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عنوان ژورنال:
- Brain : a journal of neurology
دوره 137 Pt 8 شماره
صفحات -
تاریخ انتشار 2014